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Solid State Characterization

Leading Experts in                        Comprehensive Characterization

Avomeen’s Ph.D.-led team of industry experts extend biopharmaceutical and therapeutic product lifecycles while providing invaluable insight into the physical characteristics of your materials.

Uncompromising Quality & Scientific Expertise

Avomeen’s accomplished scientists have exceptional pride in their ability to expertly design and deliver solid-state characterization and testing studies while drawing from their breadth of expertise, which extends to an array of diverse disciplines within the Life Sciences.

Polymorph screening and solid-state characterization services are performed using a variety of techniques, including Thermal Analysis, Solid State Analysis, Structure Determination and Polymorph, Co-Crystal & Salt Screening.

Read more about these techniques below.

Put Our Experts to the Test

An Unbeatable Combination of Knowledge & Multiple Techniques

Thermal Analysis

Our Ph.D.-backed teams are experts in the study of thermal properties of biopharmaceutical products and therapeutics, which include thermal decomposition, melting point, phase and glass transitions, and compound characterization. Techniques include:

  • Differential Scanning Calorimetry (DSC)
  • Thermogravimetric Analysis (TGA)


Solid State Analysis

Avomeen’s industry experts are adept at a wide range of solid-state characterization techniques, including those that are amenable to sensitive drug substances that are susceptible to form change with handling, including:

  • Powder X-Ray Diffraction (XRD)
  • Fourier Transform Infrared Spectroscopy (FTIR)
  • Hot Stage and Polarized Microscopy
  • Raman Spectroscopy
  • Particle Size Analysis


Structure Determination

Rely on the knowledge and decades of experience in structure determination to unequivocally identify molecular structures. Our respected teams of scientists are adept at defining atom-to-atom connectivity, as well as inter-molecular interactions and intra-molecular interactions with solvents and counter ions. Techniques include:

  • Solid-state Nuclear Magnetic Resonance (Solid State NMR)
  • Structure Determination
  • X-Ray Crystallography


Polymorph, Co-Crystal & Salt Screening

 Avomeen’s unrivaled scientific expertise extends beyond characterization of solid forms. While the overall performance of an active pharmaceutical ingredient (API) is directly related to its solid state form, polymorph, co-crystal, and salt screening can provide information regarding the desired physical traits and influence of the physicochemical and attributes of the crystalline or amorphous form of the API.

We have a proven track record of developing robust methods for process control of the solid-state form. Such methods may involve DSC, TGA, XRD, FTIR, or Solid-state NMR.

Why Partner with Avomeen?

Decades of experience, the capability to tailor protocols and study designs, and a readiness to take on complex and non-routine analyses results in our ability to offer a comprehensive, all inclusive-solution to our clients.

See how our approach can help transform your goals into real solutions.

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We’re Not Just Any Lab. We’re Your Lab.

In an overwhelming majority of cases, drugs and similar products are produced in solid form to ensure that consumption provides a well-balanced and rapid effect. Selecting the optimum solid form for an incredible variety of medicinal compounds is critical to the development of today’s pharmaceuticals and requires solid state characterization.

Because pharmaceutical compounds can exist in more than a single form or crystal structure, a property called polymorphism, their biopharmaceutical characteristics can change depending on their physical attributes.

Current drug polymorph screening techniques are remarkably effective at identifying and characterizing solid-state substances. With such powerful information on hand, pharmaceutical chemists can more accurately determine the optimal physical form for a drug substance as well as develop methods to ensure it does not change over time.

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