Solid State Characterization Testing
Avomeen is pleased to be able to offer solid-state characterization of drug substances and products.
We can perform a rapid screen for polymorphs involving ~ 25 crystallization conditions from 5 –6 different solvents in order to determine most of the stable polymorphs. Polymorph characterization may proceed using a variety of solid-state techniques including
- Differential Scanning Calorimetry (DSC)
- Thermal Gravimetric Analysis (TGA)
- Powder X-ray Diffraction (XRD)
- Solid State NMR
- Hot Stage and Polarized Microscopy
Typical turnaround time for a polymorph screen is 4 – 6 weeks, depending on the extent of characterization required. The study can be extended to use binary solvents, pH, and additives in order to discover and characterize the metastable forms as well. We can also develop and validate methods for process control of the solid-state form. Such methods may involve DSC, TGA, XRD, FTIR, or solid-state NMR.
Feel free to call us at 800-930-5450 for help with all of your solid-state characterization needs.